| LEOXI | Pope from the Medici family |
| LIPPI | Italian artist who was commissioned by the Medici family to create the panel paintings The Annunciat |
| FLORENCE | Once ruled by the Medici family, the capital of Tuscany, site of the Uffizi Gallery (8) |
| COSIMO | Forename of the banker depicted in portraits by his court painter Agnolo Bronzino who was the first member of the Medici family to rule Florence (6) |
| LEOX | Pope of the Medici family |
| BOTTICELLI | Florentine painter who worked for the Medici family throughout most of his life; his works include Primavera and a depiction of a goddess standing in a scallop shell in The Birth of Venus (10) |
| LORENZO | Art patron in the Medici family |
| URBAN | Old pope from the city (5) |
| SUBURBAN | Reserve pope from the outskirts (8) |
| COSMOPOLITAN | One of the Medici dropped one politician, losing half the Medici support for being so multicultural |
| FLORENTINE | Like the Medici family's chocolate-covered biscuit |
| ITALIAN | - garden; symmetrical style of alfresco space traditionally "green" with few flowers, such as any one of the many at the Medici Villas near Florence (7) |
| PITTI | Ambitious Florentine banker whose commission of a landmark palace to outshine the palazzo of his rivals, the Medici, ironically became a symbol of their enduring reign (5) |
| UFFIZIGALLERY | Where is the Medici Venus housed? (6,7) |
| RAMMED | Forced to march back by the Medici at centre (6) |
| BENEDICT | --- XVI, the Pope from 2005 to 2013 (8) |
| JOHNPAULII | He was the first pope from a Slavic country. |
| PAULVI | Pope from from 1963 to 1978 |
| INNOCENT | ... III was pope from 1198-1216 and decreed the Fourth Crusade (8) |
| AVIGNON | Which French city housed the pope from 1309 until 1376? (7) |
