| IONOSPHERE | Poison spreading in this location, a distant region |
| THULE | Ultima____, A distant region. |
| OUTERSPACE | Prosecute a maniac in distant region (5,5) |
| OORT | Dutch astronomer who first postulated the existence of a cloud in the most distant region of the solar system where long-period comets are thought to originate (4) |
| OORTCLOUD | The most distant region in our solar system named after a Dutch astronomer (4,5) |
| PLACE | A location; a public square; or, a country house with its grounds |
| STILLHERE | Whisky producer in Scotland undisturbed in this location (5,4) |
| CRIMEA | Yalta's location a Ukrainian peninsula annexed by Russia in 2014 |
| OTAGO | Share of quota good enough for distant region (5) |
| ORIENTAL | Zero cost for tenants, including one from distant region (8) |
| OUTFIELD | Distant region of cricket ground |
| FAREAST | Passenger sat, transported to distant region |
| DRAKE | English explorer heads to distant region and kisses everybody (5) |
| SOREPOINT | Putting up statue in Piccadilly location's a sensitive issue (4,5) |
| ANTRE | Cave dwellers in distant regions (5) |
| CLEMATIS | It's spreading in a flowery way from The Wall to motorway in Castile potentially (8) |
| ABOLISH | Get rid of boils spreading in a hospital (7) |
| TURPITUDE | Vileness, putrid, spreading in a day |
| STEREO | See rot spreading in a type of system (6) |
| SEASIDE | Disease spreading in area bordering a large expanse of water (7) |
