| AORTAL | Pertaining to the largest artery |
| AORTA | The largest artery in the body, conveys blood from the heart (5) |
| FUNEN | Third-largest island of Denmark, linked to the largest, Zealand, by the Great Belt Bridge (5) |
| UTRECHT | City on the Rhine, home to the largest university in the Netherlands (7) |
| TATTENHALL | Cheshire village in the Eddisbury constituency close to the 'largest ice cream shop' according to Guinness World Records (10) |
| PRADO | Home to the largest Goya collection in the world |
| ASIA | Continent home to the largest statue in the world |
| HEART | Circulatory organ from which the body's largest artery originates (5) |
| TASMANIA | An island state of Australia with the capital Hobart, home to the largest living species of marsupial carnivore (8) |
| MANCHESTER | City in New Hampshire (pop about 110,000), once home to the largest cotton mill in the world (10) |
| DETROIT | Tried to transfer and travel to the largest city in Michigan (7) |
| PASSERINE | Of or belonging to the largest order of birds, known as the perching birds or songbirds (9) |
| HANOI | Capital that's home to the largest ceramic mosaic in the world |
| ORCA | What name is given to the largest species of oceanic dolphin, also known as the killer whale? (4) |
| MARS | Home to the largest known volcano in the solar system |
| CAIRO | City which is home to the largest cinema and music industry in the Arab world (5) |
| GREATPAUL | Weighing in at nearly 17 tonnes what name is given to the largest bell in the UK in current use, heard in London? (5,4) |
| HOLLOWAY | District of the London Borough of Islington that was home to the largest women's prison in Europe until 2016 |
| TAHITIAN | Relating to the largest island of French Polynesia in the South Pacific (8) |
| EXTREME | To the largest extent (7) |
