| JAMESI | Only son of Mary, Queen of Scots |
| JAMES | First name of the son of Mary, Queen of Scots who succeeded Elizabeth I (5) |
| KINGJAMESAVERSION | Dislike of the son of Mary, Queen of Scots? |
| JAMESVI | Son of Mary, Queen of Scots |
| GUISE | Mary of ---, queen consort of James V of Scotland and mother of Mary, Queen of Scots (5) |
| MARY | --- of Guise, queen consort of James V of Scotland and mother of Mary, Queen of Scots (4) |
| ISAAC | The only son of Abraham (5) |
| HAMNET | Only son of The Bard and Anne Hathaway, ... Shakespeare |
| RANDOLPH | ___ Churchill, journalist and politician, only son of Winston (8) |
| ROB | ___ Kardashian, only son of 9A (3) |
| ALEXEI | Only son of Czar Nicholas II |
| DARNLEY | Lord -; title of Henry Stuart, husband of Mary, Queen of Scots implicated in the murder of David Rizzio before being murdered himself at Kirk o' Field (7) |
| LEVEN | Loch ___, body of water in Perth and Kinross, Scotland housing a castle that was a place of imprisonment of Mary, Queen of Scots (5) |
| STUART | Henry -, Lord Darnley; second husband of Mary, Queen of Scots and the father of James I and VI of Scotland (6) |
| WALSINGHAM | Surname of Queen Elizabeth I's spymaster who secured the execution of Mary Queen of Scots (10) |
| BOTHWELL | Earl of ___, third husband of Mary Queen of Scots (8) |
| ANTOINETTE | ___ of Bourbon, grandmother of Mary, Queen of Scots |
| RUDOLF | Third child and only son of Austrian emperor Franz Joseph I, titled crown prince (1858-89) (6) |
| SETH | Other than Cain and Abel, the only son of Adam and Eve mentioned by name in the Bible |
| ORESTES | Only son of Agamemnon and Clytemnestra, brother to Iphigenia, Electra and Chrysothemis (7) |
