| SANGER | Only person to have won the Nobel Prize in Chemistry twice (last name only) |
| PAULING | The only person to have won the Nobel Prize for Chemistry and for Peace, and known for his research in quantum chemistry and molecular biology (last name only) |
| WORLDWAR | The globe suffered this all-out conflict twice last century (5,3) |
| SCHALKBRITS | Ex-Saracens hooker who captained South Africa twice last year (6,5) |
| MIRREN | Only person to have won the Triple Crown of Acting in both the U.S. and the U.K. |
| FREDWINTER | The only person to have won the Cheltenham Gold Cup, Champion Hurdle and Grand National as both jockey and trainer |
| DAWNSTALEY | Only person to have won the Naismith Award as both player and coach |
| RUTHPRAWERJHABVALA | The only person to have won both a Booker Prize and an Oscar (4,6,8) |
| LINUSCARLPAULING | US chemist who became the only person to have won two unshared Nobel Prizes (5,4,7) |
| ROSSI | Who is the only football player in the world to have won the World Cup, Golden Boot, Golden Ball and Ballon d'or awards - all four in the same year? (5) |
| SURTEES | Six-time worid 500cc motorcycle champion who became F1 champion in 1964, the only person to have won both titles (7) |
| HEPBURN | Who is the only person to have won four Academy Awards for acting? (7) |
| RODLAVER | The only person to have won tennis's Grand Slam as an amateur and a professional (3,5) |
| BORA | Identify the first name of this Serbian who is the only person to have been the manager of five different countries in five consecutive World Cups. (4) |
| GEORGEDEWEY | The only person to have been appointed Admiral of the Navy in the US (6,5) |
| TARKINGTON | Author of the Penrod stories and The Magnificent Ambersons, who is one of only four novelists to have won the Pulitzer Prize for Fiction twice (10) |
| CHICAGO | The only musical to have won the Oscar for Best Picture in the 21st century (7) |
| GRITTAR | Horse that won the 1982 Grand National, ridden by amateur jockey Dick Saunders, who at the age of 48 was the oldest jockey to have won the race (7) |
| OUSMANE | Identify the first name of this Frenchman who figured in both 2018 and 2022 teams and is also one of the 10 players to have won the World Cup, UEFA Champions League and Ballon d'or. (7) |
| BELUSHI | Only person to have the #1 movie, #1 album and #1-rated late-night TV show all in the same week |
