| EMI | One of the "Big Four" record companies |
| LNER | Abbreviated form of the second-largest of the "Big Four" railway companies created by the Railways Act of 1921 |
| GEORGE | Regnal name of British Monarch on the throne at the time of the Big Four Grouping in 1923 (6) |
| GOOGLE | One of the Big Four tech. companies |
| KPMG | One of the "Big Four" accountancy firms. (1,1,1,1) |
| NADAL | One of the Big Four in tennis |
| SONY | One of the "Big Four" labels |
| NAB | One of the big four banks |
| EY | One of the big four accounting firms, abbr. (2) |
| TWA | One of the "Big Four" domestic carriers, once |
| ANTHRAX | One of the "Big Four" thrash metal bands |
| CITI | One of the big four banks |
| WELLSFARGO | One of the "Big Four" banks [2] |
| JPMORGANCHASE | One of the Big Four US banks |
| PWC | One of the Big Four accounting firms. (1,1,1) |
| ERNST | EY (___ & Young) is one of the Big Four accounting firms. (5) |
| EASTERN | The E of LNER, one the 'big four' railways companies that flourished in the UK before the government takeover of services |
| LMS | Biggest of the 'Big Four' (initials) (3) |
| GRAMMY | Award notably won in each of the "big four" categories by this puzzle's honoree |
| DELOITTE | Member of the "Big Four," along with Ernst & Young, KPMG, and PwC |
