| RANCHMAN | One handling stock finding glimmer of hope in new mRNA vaccine cutting odds |
| MODERNA | mRNA vaccine maker |
| WINNIETHEPOOH | He won't, I hope, in new children's book |
| BIOTECH | mRNA vaccines' field |
| NOSERINGS | Aids for handling stock or facial ornaments (4,5) |
| RAY | Word for a line of light or beam of sunshine, thus a glimmer of hope or a gleam of intellectual illumination (3) |
| SHINE | Glimmer of hope's beginning for power in backbone |
| CLINTON | One with a glimmer of Hope? |
| CRAYON | It's a disadvantage hiding glimmer of hope for colourful writer (6) |
| OFTHE | Glimmer of hope when emerging from underground passage (5,2,3,3,2,3,6) |
| ATTHEEND | Glimmer of hope when emerging from underground passage (5,2,3,3,2,3,6) |
| TUNNEL | Glimmer of hope when emerging from underground passage (5,2,3,3,2,3,6) |
| LIGHT | Glimmer of hope when emerging from underground passage (5,2,3,3,2,3,6) |
| UPTURN | Glimmer of hope? |
| XRAYING | Having a look inside of Times for a sign of hope in Government (1-6) |
| RAINBOW | Sign of hope in part of London led by artist (7) |
| RETREAT | 'Flight' line from turn in fact cutting odds (7) |
| TRNA | The form of RNA that attaches the correct amino acid to the protein chain that is being synthesized at the ribosome of the cell (according to directions coded in the mRNA). |
| GLIMMER | May one have ___of hope in gutter? (7) |
| OBAMA | President who wrote "The Audacity of Hope" in 2006 |
