| SELDOM | Once in a while, wee Lesley goes back to Dominic briefly (6) |
| ZVEREV | Alexander, German tennis player who lost to Dominic Thiem in the 2020 U.S. Open final (6) |
| NEEDLES | Require wee Lesley to fetch items for the dressmaker (7) |
| SOPHOCLES | In posh company, Lesley goes on about old playwright (9) |
| RARELY | Once in a while, rock-and-roll headlines at place in Dublin (6) |
| YEARLY | Listen to wise Lear once in a while (6) |
| SYSTEM | Say, as it seems to be once in a while arrangement (6) |
| TOTIME | Occasionally, and once in a while, in other words (4,4,2,4) |
| ROTTEN | How you might feel, once in a while |
| HARDLY | Every once in a while |
| OCCASIONALLY | 16dn, once in a while, in a word! (12) |
| FROMTIME | Occasionally, and once in a while, in other words (4,4,2,4) |
| ATTIMES | A little cheat, Tim, escapes once in a while (2,5) |
| OCCASIONAL | As a colonic irrigation is once in a while (10) |
| ELASTIGIRL | Mom who needs to stretch her legs once in a while? |
| MISSME | Question from someone you haven't seen in a while |
| RISKYBUSINESS | 1983 movie with the line "Every once in a while you just got to say 'what the heck' and take some chances" (2 wds.) |
| COMET | Arden's asleep, seen once in a while (5) |
| APERIODIC | Copy Brazilian city detectives, turning up every once in a while (9) |
| COPYIST | Once in a while actor pays one small time imitator (7) |