| MUSH | Obstacle in 65-Across that causes the titular enemy to 21-Across/61-Across |
| CAPITAL | One can be seen in 17-Across, 61-Across, 11-Down, and 29-Down |
| LEONARD | With 54-Across, 61-/64-/66-Across composer |
| TAPETUM | Membranous layer of reflective cells behind the retina in some animals that causes the eyes to glow in the dark (7) |
| HOOK | In golf, a shot that causes the ball to go to the player's left (4) |
| FADE | Golf shot that causes the ball to deviate to the right (or, for a left-handed player, the left) (4) |
| ALLERGY | A hypersensitivity to a substance that causes the body to react to any contact with it (7) |
| EVIL | Like the serpent in 65- Across |
| THROMBIN | Enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin (8) |
| JAUNDICE | Blood disorder that causes the skin and white of the eye to turn yellow (8) |
| MUMPS | Illness that causes the swelling of glands in the neck (5) |
| TRANSFORA | Route from Viminal to 21, across the (imperial) forums |
| ABERRATION | In optics, a defect in a lens or mirror that causes the formation of either a distorted image or one with coloured fringes |
| FROUFROU | Four/four alternation? That causes the swish of the skirt! (8) |
| TILT | Feature of the earth's axis that causes the seasons |
| DOA | "___ barrel roll" (Google search that causes the page to rotate 360 degrees) |
| SOFTPEDAL | Device on a piano that causes the hammer to strike only one string (una corda) (4,5) |
| ANKLE | ___ breaker, basketball move that causes the defender to fall over |
| MACHINE | In '65 Vinny Price invented a bunch of girl robots in Dr. Goldfoot and the Bikini _______. |
| FOLIC | They say that Vitamin B acid is the enemy to beat (5) |
