| SACREDCOW | Nickname of the first US presidential aircraft |
| ABE | Nickname of the first US president to be assassinated |
| TEDDY | Nickname of the first US president to appoint a Jewish cabinet member (5) |
| ROUGHRIDERS | Nickname of the 1st US Volunteer Cavalry Regiment during the Spanish-American War |
| RAMBLER | Which Nash car model of the early 1950s was considered to be the first US compact car? (7) |
| ANTON | Helen Hayes starred in the first US TV adaptation of ... Chekov's The Cherry Orchard |
| REXTILLERSON | The first US secretary of state chosen by Donald Trump |
| TEDDYROOSEVELT | Informally, the first US president to win the Nobel peace prize |
| JOHNGLENN | The first US astronaut to orbit the earth, in 1962, circling it thrice (4,5) |
| TYLER | In 1841, John ____ became the first US vice president to succeed to the presidency without election |
| BOBBYFISCHER | In 1972, who became the first US chess player to win the world championship? (5,7) |
| PEPSI | What was the first US consumer product sold in the Soviet Union? (5) |
| WYOMING | Which was the first US state to give women the vote? (5) |
| ALABAMA | Alphabetically, which is the first US state? (7) |
| DEL | The first US state: Abbr. |
| NIXON | Who was the first US president to resign? (5) |
| SHEPARD | Alan, the first US astronaut to travel in space (7) |
| TUTTIFRUTTI | In 1955, the first US hit for Little Richard (5,6) |
| ROSS | Betsy who is said to have created the first US flag |
| SKYLAB | The first US space station (1973 to 74) (6) |
