| CULPEPER | Nicholas --, English herbalist and astronomer (1616-54) (8) |
| HILLIARD | Nicholas, English miniaturist portrait painter (8) |
| MARJORAM | Herbalist, in a manner of speaking, lays arm on major (8) |
| TURMERIC | Herbalist may use this in old city breaking complicated metric (8) |
| LEMAITRE | The priest and astronomer who first proposed the Big Bang theory (8) |
| GRIMALDI | Francesco Maria -, 1618-1663, Italian physicist and astronomer (8) |
| HATHAWAY | Wife of playwright William Shakespeare from 1582 until his death in 1616 (8) |
| CROMWELL | Redhead who entered Cambridge in 1616 |
| SELFHEAL | What the herbalist uses when he, personally, needs medication? (4-4) |
| LODESTAR | Real dots arranged as a guide for sailors and astronomers (8) |
| ALOEVERA | Herbalist's supply for a love area |
| ALLHEALS | Herbalists' panaceas |
| UDALL | Nicholas -, English schoolmaster who wrote the play Ralph Roister Doister (5) |
| HOULT | Nicholas, English actor who played mutant Hank McCoy in the X-Men film series (5) |
| INIGOJONES | Influential English architect whose works include the Queen's House at Greenwich (1616-19) and the Banqueting House at Whitehall (1619-22) (5,5) |
| HAKLUYT | Richard --, English geographer (c.1552-1616) (7) |
| SHAKESPEARE | English dramatist, 1564-1616 (11) |
| ISAAC | ___ Newton English mathematician and astronomer |
| OMARKHAYYAM | Which Persian mathematician and astronomer wrote the poem RubAyat (4,8) |
| PESTLE | Herbalist's tool crushed peel around bits of sage and thyme (6) |
