| VESPUCCI | Navigator Amerigo, who made voyages to the New World in the late 15th and early 16th centuries (8) |
| AMERIGOVESPUCCI | Italian explorer and navigator, 1454-1512, who made voyages on behalf of Spain and Portugal (7,8) |
| REIS | Portuguese coins in circulation between the 15th and early 20th centuries (a) |
| GODSPEED | One of the three ships on the voyage to the New World that resulted in the founding of Jamestown |
| COLUMBUS | Christopher, explorer who landed in the New World in 1492 (8) |
| ISABELLA | Queen of Castille who sponsored Columbus' voyages to the Americas (8) |
| NEWWORLD | Term used from the early 16th century to describe North and South America (3,5) |
| FROBISHER | 16th Century English sea captain who made three voyages to the New World looking for the North-west Passage |
| CODPIECE | Pouch sewn into the front of a man's breeches in 15th and 16th-century dress |
| EVERYMAN | English morality play of the early 16th century (8) |
| ARMAND | Character in The Vampire Chronicles novels by Anne Rice born in the late 15th Century to the hunter Ivan |
| CONQUISTADOR | Military leader in the Spanish conquest of the New World in the 16th century (12) |
| OTTOMAN | Created in Anatolia (Asia Minor), this empire grew to be one of the most powerful states in the world during the 15th and 16th centuries. It came to an end in 1922, when it was replaced by the Turkish |
| NINA | What ship, with the Pinta and the Santa Maria, did Christopher Columbus command on his first voyage to the New World in 1492? (4) |
| SISTINE | The ____ Chapel is named after the pope for whom it was built, in the late 15th century |
| MAYFLOWER | Springtime blossom of hawthorn; the trailing arbutus; or, the ship in which the Pilgrim Fathers sailed from Plymouth to the New World in 1620 (9) |
| MIDDLEAGES | The period of history from the 5th to the late 15th centuries (6,4) |
| TRUDEAUS | 15th and 23rd Canadian PMs |
| AULICCOUNCIL | Judicial body of the Holy Roman Empire organized by Maximilian I in the late 15th century |
| WALTER | English writer, soldier, courtier and explorer who first sailed to the New World in 1578 (6,7) |
