| TAPSTER | Much of his life is spent behind bars |
| ARCHAEOLOGIST | A lot of his life is in ruins (13) |
| AMEBA | Its whole life is spent in a tiny cell |
| POTTERS | Their working day is spent behind the wheel (7) |
| JAMESBALDWIN | Expat Afro-American poet who spent much of his life in Paris. His novels, essays, and activism solidify him as a crucial figure in the Harlem Renaissance movement. |
| LIVINGSTONE | Which Scottish missionary and explorer spent much of his life searching for the source of the Nile, and was himself discovered by H. M. Stanley? (11) |
| OSLO | Capital of Norway, where artist Edvard Munch lived for much of his life (4) |
| SISLEY | British Impressionist painter, 1839- 1899, who spent much of his life in France (6) |
| BENDA | Bohemian composer and virtuoso violinist who worked for much of his life at the court of the flautist future Frederick the Great (5) |
| EXPAT | Henry James, for much of his life |
| DUAL | Like Ted Cruz's citizenship, for much of his life |
| CHAGALL | Artist born in modern-day Belarus who resided in France for much of his life |
| LIBRAN | According to his horoscope, his life is in the balance |
| MONK | His life is in order |
| MILLER | His life is one long grind (6) |
| OGLE | _ Design, where Tom Karen spent much of his career (4) |
| CHAGATAI | Second son of Genghis Khan, 1183-1242, who inherited much of his empire (8) |
| ASEA | Like Phileas Fogg during much of his journey |
| LALAKER | Shaq, for much of his career |
| DENTIST | He fills much of his working day |