| HAGIASOPHIA | Mosque in Istanbul, once the world's largest cathedral |
| IZMIR | Second-largest Turkish port after Istanbul, once the ancient city of Smyrna (5) |
| SOPHIA | Building in Istanbul that was the largest cathedral in the world for nearly a thousand years until the completion of the Seville Cathedral in 1520 |
| HAGIA | Building in Istanbul that was the largest cathedral in the world for nearly a thousand years until the completion of the Seville Cathedral in 1520 |
| AMIENS | The opening battle of the Hundred Days Offensive in WWI started in this city where the largest cathedral in France can be found |
| NOOR | Koh-i-___, once the world's largest known diamond |
| SEARS | Once the world's largest retailer |
| SNL | TV series airing from what was once the world's largest radio studio |
| CONSTANT | Unchanging, like more than half of Istanbul once |
| UPPSALA | Swedish city, home to Scandinavia's largest cathedral (7) |
| CAPITALOFTURKEY | Istanbul once, Ankara today |
| ISLAM | The Grand Mosque in Mecca is considered the most sacred site in this religion (5) |
| SAUDIARABIA | Kingdom sometimes called 'The Land of The Two Holy Mosques' in reference to Mecca and Medina, the two holiest places in Islam (5,6) |
| DEARBORN | Michigan city home to the largest mosque in North America |
| CORDOBA | City in Andalusia, Spain, originally built as a mosque in the 8c (7) |
| HARAMALSHARIF | Al-__-__, Arabic name for the Temple Mount, site of the al-Aqsa mosque in East Jerusalem (5,2-6) |
| GETTY | Book and art collector who married Talitha Pol in 1966; the son of an oil baron once the world's richest man (5) |
| ARAL | Sea once the world's fourth-largest lake |
| NINEVEH | Bygone city in present-day Iraq, once the world's most populous |
| ARALSEA | Body of water that was once the world's fourth-largest lake |