| CODEINE | Morphine derivative used as a sedative (7) |
| EUCAINE | Cocaine derivative used as a local anaesthetic (7) |
| SPICE | Plant or vegetable derivative used as a culinary ingredient - cinnamon, cloves, cumin, turmeric to name a few (5) |
| VALERIAN | The name of a Roman emperor and a herb used as a sedative (8) |
| SNUFF | At a pinch it may be used as a sedative |
| NEMBUTAL | Trade name of the drug pentobarbital, a barbiturate which can be used as a sedative or, for animals, |
| BARBITURATE | A type of depressant drug used as a sedative or sleeping pill (11) |
| BARBITAL | An acid formally used as a sedative (8) |
| SLEEPER | A dormant spy awaiting activation; a beam that holds a rail track in place at the correct gauge; or, an informal word for a sedative (7) |
| CHLORAL | Performed by singers restraining novice with a sedative (7) |
| BROMIDE | Order the wife to swallow a sedative (7) |
| OPIATE | As a sedative, I had a meal after work (6) |
| DEMEROL | A sedative |
| AGRIMONY | From Greek for "poppy", thought due to its ancient use as a sedative, a plant with spikes of yellow flowers, hence its other names including church steeples, fairy wand and sticklewort (8) |
| BARBITONE | Singer takes vitamin as a sedative (9) |
| SEED | Poppy part that may act as a sedative |
| ISITANYDOWNER | "Does this medication act as a sedative at all?"? |
| SOPORIFIC | Blend of crop is containing iodine as a sedative (9) |
| KNOCKOUT | Blow these drops as a sedative (8) |
| HEROIN | Brave person in production of a morphine derivative |
