| DLI | Middle of the sixth century |
| DAD | Parent at the start of the sixth century? |
| JOHNI | Martyred pope of the sixth century |
| EZEKIEL | Hebrew prophet of the sixth century BC (7) |
| DIASPORA | Dispersion of a population from its homeland, as of the Jews after the Babylonian captivity of the 6th century BC (8) |
| THESPIS | Greek poet of the 6th century B.C. credited with originating the role of the actor in drama (7) |
| AESOP | Supposed Greek fabulist of the 6th century BC first attested by the historian Herodotus a century later (5) |
| STDAVID | Leader of the 6th. century monastic revival in Wales? (2.5) |
| SAPPHO | A Greek lyric poetess of the 6th Century BC (6) |
| ANACREON | Greek lyric poet of the 6th century BC known for his drinking songs (8) |
| TARA | The seat of Irish kings until the sixth century (4) |
| BACTRIA | Ancient region spanning parts of modem Afghanistan, Uzbekistan and Tajikistan, probably subdued in the sixth century BC by Persian king Cyrus the Great (7) |
| ARAMAIC | Language used as a lingua franca in the Near East from the sixth century BC |
| BENEDICTINES | Monks or nuns of a Christian religious order founded in the sixth century (12) |
| COLU | Which Irish saint founded a famous monastery on Iona in the Sixth Century? (7) |
| TEMPLEOFARTEMIS | One of the Seven Wonders of the Ancient World, originally built in Ephesus in the 6th century BC (6,2,7) |
| OCTA | An Anglo-Saxon King of Kent during the 6th century who appears in Geoffrey of Monmouth's Historia Regum Britanniae |
| CHESS | One of the oldest and most popular board games, developed around the 6th century CE |
| TALIESIN | Chief of the bards in Welsh myth and legend, believed to have lived in the 6th century (8) |
| FRANK | Member of the Germanic peoples who conquered Gaul in the 6th Century and gave their name to a new country (5) |
