| FRIDAKAHLO | Mexican painter who starkly portrayed pain and the harsh lives of women: 2 wds. |
| OBOE | Its "reeds are a pain / And the fingering's insane," per Ogden Nash |
| EISENBERG | Jesse _, actor whose films include A Real Pain and The Social Network (9) |
| LUKEEVANS | Welsh actor who landed the starring role in "Professor Marston and the Wonder Women": 2 wds. |
| MELINDAGATES | Cochair of America's largest private foundation and #5 on Forbes's 2020 list of The World's 100 Most Powerful Women: 2 wds. |
| ANGELAMERKEL | German chancellor since 2005 and #1 on Forbes's 2020 list of The World's 100 Most Powerful Women: 2 wds. |
| KAMALAHARRIS | US vice president and #3 on Forbes's 2020 list of The World's 100 Most Powerful Women: 2 wds. |
| JANHOOKS | Late actress who was on Saturday Night Live and Designing Women: 2 wds. |
| DIEGORIVERA | Mexican painter who married painter Frida Kahlo, twice (5,6) |
| KAHLO | Frida, Mexican painter who married the muralist Diego Rivera (5) |
| ANNIEPOTTS | Co-star to Delta Burke and Jean Smart on "Designing Women": 2 wds. |
| ANTARCTICA | Also known as the White Desert. The harsh cold of this continent limits average precipitation (liquid water equivalent) is only about 2 inches (50 mm) per year over the polar plateau. |
| RIVERA | Diego -, Mexican painter who died in 1957 (6) |
| SPARTAN | Starkly disciplined and austere in the manner of Athen's ancient enemy |
| MESHACHTAYLOR | He played Anthony Bouvier on "Designing Women": 2 wds. |
| DELTABURKE | She played Suzanne Sugarbaker on "Designing Women": 2 wds. |
| BRAY | The harsh heehaw of a donkey; or, any similar loud grating sound (4) |
| JAROWL | Another name for the goatsucker, from the harsh noise it makes |
| BRAE | We hear the harsh cry of a donkey in a Scots hillside (4) |
| COED | Dorm for men and women (2-2) |
