| APACHE | Member of a North American Indian people inhabiting the southwestern US and N. Mexico (6) |
| PUEBLO | A communal village in the southwestern US and parts of Latin America, consisting of one or more stone or adobe houses (6) |
| NAVAJO | A member of a North American Indian people of Arizona, New Mexico and Utah |
| OJIBWA | A member of a North American Indian people living in a region west of Lake Superior (6) |
| COMANCHE | Member of a North American people of the southwestern US - and a popular cultivar of waterlily! (8) |
| SENECA | Member of a North American Indian people formerly living south of Lake Ontario (6) |
| MESCAL | Alternative name for the peyote cactus (Lophophora williamsii) of Mexico and the southwestern US (6) |
| JOJOBA | Shrub of southwestern us and Mexico grown for waxy oil in its seeds (6) |
| PEYOTE | Spineless globe-shaped cactus of Mexico and the southwestern US that is also called mescal (6) |
| ESKIMO | Member of an indigenous people inhabiting the Arctic region (6) |
| ARROYO | In the southwestern US, a creek bed that is usually dry, but fills with water after heavy rain (6) |
| ROSITA | Erect plant of the southwestern United States, Centaurium calycosum, having small clusters of pink trumpet-shaped flowers (6) |
| GILAMONSTER | Large, venomous, brightly coloured lizard inhabiting deserts of the southwestern US and Mexico (4,7) |
| SACHEM | A North American Indian chief |
| RANCHO | A hut housing agricultural workers in the southwestern US |
| PINOLE | In the southwestern United States, flour made of parched ground corn, mesquite beans, sugar, etc. |
| OTO | A member of the Siouan people inhabiting the valleys of the Platte and Missouri rivers in Nebraska. |
| OTOE | A member of the Siouan people inhabiting the valleys of the Platte and Missouri rivers in Nebraska. |
| NAVATO | Language of the Southwestern United States |
| MOJAVE | Desert in the Southwestern United States (6) |
