| GARNEAU | Marc ___ (The first Canadian astronaut in space, in 1984) |
| MARCGARNEAU | Minister of Foreign Affairs who in 1984 became the first Canadian astronaut in space: 2 wds. |
| SPACEWALK | As per #26-Down... In 2001, Chris Hadfield became the first Canadian astronaut to perform this free-floating promenade way above the Earth |
| ROBERTABONDAR | Mission STS-42... Astronaut who became the first Canadian woman in space in 1992: 2 wds. |
| VIRGIL | TV's Thunderbirds craft were piloted by Scott, Alan, Gordon, John and ..., all named after the first US astronauts in space |
| JOHN | TV's Thunderbirds craft were piloted by Virgil, Scott, Alan, Gordon and ..., all named after the first US astronauts in space |
| UNSUITED | Inappropriate, like a naked astronaut in space? (8) |
| GUSGRISSOM | Second U.S. astronaut in space, after Alan Shepard |
| ALANSHEPARD | US astronaut who became the first to travel in space in 1961 (4,7) |
| MARC | First name of the first Canadian man in space |
| WEIGHTLESSNESS | Condition felt by astronauts in space (14) |
| SALLYRIDE | The first American woman in space (in 1983) |
| RIDE | She became the first American woman in space in 1983 |
| EDWHITE | The first American to "walk" in space, in 1965 |
| PEAKE | Tim, first official British astronaut to walk in space in 2016 (5) |
| FERGIEJENKINS | Legendary pitcher born in Chatham, Ontario who in 1991 became the first Canadian inducted into the National Baseball Hall of Fame: 2 wds |
| AGNES | First name of the first Canadian woman elected to the house of commons |
| SPACESHUTTLE | The one Canadian astronaut Roberta Bondar was a crew member on in 1992 for Mission STS-42 was called the Discovery: 2 wds. |
| GLENN | John - - -, American astronaut who became the oldest person to fly in space in 1998 (5) |
| ATTIC | It upset cat it found in space in the roof (5) |
