| HALLE | Manchester-based symphony orchestra founded in 1858 |
| YWCA | Youth org. founded in 1858 |
| HALL | Manchester-based orchestra slightly too big for this concert venue |
| RINGSPUN | Manchester-based fashion brand launched by David Mallon in 1999 |
| OASIS | Place offering refreshment in heat for Manchester-based group (5) |
| EDDYSHAH | Manchester-based businessman who founded the tabloid Today (4,4) |
| AERTEX | Manchester-based clothing company, established in 1888, that owns the trademark for a lightweight and loosely woven cotton fabric used chiefly for sportswear |
| BELLE | Vue Aces, Manchester based speedway team (5) |
| BELLEVUEACES | Manchester-based speedway team; National League champions from 1933-36 |
| HALLEORCHESTRA | Manchester-based players intent on scoring? |
| AREA | Manchester-based speedway team (5,3,4) |
| ACES | Manchester-based speedway team (5,3,4) |
| VUE | Manchester-based speedway team (5,3,4) |
| HERMANSHERMITS | Manchester-based pop group featuring lead singer Peter Noone |
| WIGAN | Greater Manchester-based football club, - - - Athletic |
| BELLEVUE | & 2D Manchester-based speedway team; National League champions from 1933-36 |
| REFUGE | Life insurance and pensions company founded in Cheshire in 1858 (6) |
| LOURDES | Town in France in which Bernadette Soubirous claimed to have visions of the Virgin Mary in 1858 |
| MACY | Rowland H. , U.S. businessman who founded a department store chain in New York in 1858 (4) |
| GRAYS | First published in 1858, _____ Anatomy is still in use today. (5) |