| TITICACA | Lying high in the Andes Mountains, astride the border between Peru and Bolivia, it is the second largest lake in South America (8) |
| ALSTON | Market town in Cumbria lying high in the North Pennines (6) |
| HELIUM | Noble gas whose chemical symbol is He. Used in welding and rocket fuel, it is the second, lightest known element. |
| USED | It is the second-hand one is accustomed to (4) |
| APRIL | It is the second to be rhymed for thirty days (5) |
| LAKETITICACA | Attack CIA lie about what's located in the Andes, between Peru and Bolivia |
| COTOPAXI | Stratovolcano in the Andes Mountains that is the second highest summit in Ecuador |
| LAPAZ | Largest city and de facto capital of Bolivia, in the Andes mountains southeast of Lake Titicaca (2,3) |
| LASCAR | Volcano in northern Chile in the Andes mountains (6) |
| MACHUPICCHU | Ancient site located high in the Andes and often referred to as 'The Lost City of the Incas' (5,6) |
| ATACAMA | And 39 Large arid region of northern Chile on the Pacific coast west of the Andes mountains (7,6) |
| LLAMA | Alpaca relative in the Andes mountains |
| PERU | South American country in the Andes mountains |
| INCA | Civilization in the Andes Mountains about 500 to 800 years ago |
| BOLIVAR | Politician and military leader, 1783-1830, who became president of Venezuela, Peru and Bolivia (7) |
| DESERT | Large arid region of northern Chile on the Pacific coast west of the Andes mountains (7,6) |
| MACHU | This Inca city is situated over 2,000 metres high in the Andes, ... Picchu |
| ALIVE | This film detailed a Uruguayan rugby team's 1972 plane crash into the Andes mountains (5) |
| ALTO | It's high in the Andes |
| ECUADOR | Country between Peru and Colombia (7) |
