| CHANEL | Losing heart, what separates us from the French designer |
| HOMER | TV character who says "Weaseling out of things is important to learn. It's what separates us from the animals ... except the weasel" |
| INGREDIENT | Cook determining, having lost heart, what to put in food (10) |
| BETWEENYOUANDME | Where what separates us is to be kept secret (7,3,3,2) |
| BLOODBANKS | Relatives on both sides of The Liffey, for instance, bound to give the bleeding hearts what they need (5,5) |
| TICKLER | Lover originally having broken heart, what's so amusing? (7) |
| ACCORD | Pact, at heart, what's needed for binding agreement |
| LITERATI | They may take to heart what's found in e.g. Kim, Kipps and Kidnapped |
| IRISHSEA | It separates us from Britain (5,3) |
| TASMANSEA | Expanse of water that separates us from Australia (6,3) |
| RIOTOUS | Being wild, there's nothing to separate us from an unruly trio (7) |
| DIXIE | Informal name for the Southern states of the US, from the title of a song written by Daniel Decatur Emmett in 1859 (5) |
| PURCHASE | Louisiana _, the 1803 acquisition of Louisiana by the United States from the French First Republic (8) |
| AND | What separates the lead singer from the band? |
| WEBBEDFEET | What separates the gulls from the buoys? |
| AGEGAP | What separates the men from the boys? |
| RIDDLE | Problem: what separates the wheat from the chaff? (6) |
| ENGLISHCHANNEL | What separates Britain from the continent? The BBC? (7,7) |
| WELLSFARGO | Pioneer mail courier and banking service that operated in the western US from the mid-19th century (55) |
| RAGTIME | Style of syncopated piano music popular in the US from the 1890s to 1910s (7) |