| STEVENAGE | Located in Hertfordshire, the UK's first new town (9) |
| KNEBWORTH | --- House, mansion in Hertfordshire, the former home of Sir Edward Bulwer-Lytton (9) |
| KNEBWORTHHOUSE | Tudor mansion in Hertfordshire; the former home of Sir Edward Bulwer-lytton (9,5) |
| SPACEPORT | Sutherland is to have the UK's first one (9) |
| THEDAMNED | Band who released the UK's first punk single, in 1976 |
| ADDINGTON | Prime minister from 1801-04 later titled 1st Viscount Sidmouth who delivered the UK's first budget speech (9) |
| ERNIEWISE | Comedian once thought to have made the UK's first mobile phone call |
| ROTTENROW | Avenue of Hyde Park, the UK's first artificially lit highway |
| NEOLOGISM | One new entry is Merriamwebster's first new word (9) |
| KERIHULME | First New Zealand writer to win the Booker Prize, for The Bone People (4,5) |
| DIAGNOSED | Analyzed Dion's first new song idea (9) |
| ASSISTANT | Like second coffee? Send out first new aide (9) |
| EASTKILBRIDE | Scotland's first new town (4,8) |
| GILHODGES | Future Miracle Mets manager who hit the first New York Mets homer (1962): 2 wds. |
| WEREFRANK | "Our ticket had the winning numbers!!!" ("I've known him for years. He asked me to read his first New York Times op-ed before it was published.") |
| SWEETNESS | Sets seen with first new pleasing taste |
| EPSOM | Surrey town in which the UK's first automatic telephone exchange was installed in 1912 (5) |
| GOWER | Peninsula in Wales including the Mumbles and Rhossili Bay that was designated as the UK's first Area of Outstanding Natural Beauty in 1956 (5) |
| JOHNELLIOTBURNS | ____, the UK's first working-class cabinet minister (in 1905) later coined the phrase "The Thames is liquid history" |
| REACTOR | The UK's first was opened at Calder Hall in Cumbria in 1956 (7) |
