| JOHNBROWN | Leader of infamous 1859 raid |
| ISOMER | Leader of infamous county set's abandoned compound |
| HARPERSFERRY | Site of John Brown's 1859 raid |
| CONCENTRATION | The sort of infamous camp that took a lot of thought to organise? (13) |
| MARCOS | Surname of infamous shoe-hoarder (6) |
| KRAY | Surname of infamous East End twins. (4) |
| RASPUTIN | Somehow ruin past of infamous Russian monk (8) |
| CADDISFLY | Storage box traps wings of infamous and foul insect (6,3) |
| ZAMMO | Nickname of infamous 1980s Grange Hill character Samuel Mcguire (5) |
| DURBAN | Site in 8 DOWN of infamous antisemitic conference (6) |
| DARWIN | Charles ?, author of 1859 scientific work On the Origin of Species by Means of Natural Selection (6) |
| OMARKHAYYAM | "The Rubaiyat of ... ...", 1859 translation of 12th Century Persian poems by Edward Fitzgerald (4,7) |
| MEREDITH | George ___, author of 1859 novel The Ordeal of Richard Feverel (8) |
| AGASSIZ | Louis -, Switzerlandborn geologist; founder in 1859 of the Museum of Comparative Zoology at Harvard University (7) |
| IASI | City on the Bahlui River in NE Romania; capital of the principality of Moldavia from 1564 to 1859 (4) |
| DIXIE | Informal name for the Southern states of the US, from the title of a song written by Daniel Decatur Emmett in 1859 (5) |
| ARRHENIUS | Svante August ___, (1859-1927), Swedish chemist and physicist noted for his work on the theory of electrolytic dissociation and his model of the greenhouse effect: Nobel Prize for Chemistry 1903 (9) |
| DARWINISM | Theory of biological evolution first formulated in the 1859 work On the Origin of Species (9) |
| GEORGESSEURAT | French artist born in 1859 who pioneered a technique of painting in small dots of colour (7,6) |
| ELIOT | George ___, pen name of the author of novels including Adam Bede (1859) and Middlemarch (1871-2) (5) |
