| CESAREBORGIA | Italian cardinal and mercenary leader, the main antagonist in the video game Assassin's Creed: Brotherhood |
| CONDOTTIERE | Italian mercenary leader (historical) |
| BOWSER | The main antagonist in the Super Mario video game franchise |
| SNOW | Coriolanus ___, ruler of Panem and the main antagonist in The Hunger Games series of novels |
| BIFF | Forename of the main antagonist in the Back to the Future films (4) |
| MONICA | Bellucci, Italian actress who played the main antagonist in the 2024 film Beetlejuice Beetlejuice (6) |
| DOUGRAYSCOTT | Actor who played the main antagonist in the 2000 action spy film Mission: Impossible II (7,5) |
| IAGO | The main antagonist in the Shakespeare play Othello (4) |
| NAPOLEON | Pastry also called a millefeuille; or, the main antagonist in George Orwell's novella Animal Farm (8) |
| PINKIE | Nickname of the main antagonist in Graham Greene's 1938 novel Brighton Rock |
| OTTO | ____ West (played by Kevin Kline) is the main antagonist in A Fish Called Wanda |
| ANGELO | Who is the main antagonist in Shakespeare's play Measure for Measure? (6) |
| COLEMAN | Dabney ___, late US actor whose film roles included the main antagonist in 9 To 5 (7) |
| PLANKTON | Sheldon and Karen, the main antagonists in animated children's series SpongeBob SquarePants (8) |
| BORGIA | Cesare, Italian cardinal and politician who was the model for Machiavelli's The Prince (6) |
| ROTH | Hyman ___, main antagonist in "The Godfather Part II" |
| FAGIN | Main antagonist in the Charles Dickens novel 'Oliver Twist' (5) |
| ROYBATTY | Main antagonist in the film Blade Runner |
| VOLDEMORT | Main antagonist in the Harry Potter series of novels (9) |
| MALVOLIO | The main antagonist in Twelfth Night (8) |
