| ISLEROYALE | Island in NW Lake Superior, Michigan, forming part of a US National Park (4,6) |
| ROYALE | Isle ... is an island in NW Lake Superior that houses a National Park (6) |
| COWCATCHER | Part of a US locomotive that's for rolling stock? (10) |
| GREATLAKES | Superior, Michigan, Huron, Erie and Ontario (5,5) |
| LBJRANCH | Presidential retreat now part of a US National Historical Park |
| YOSEMITE | A US National Park |
| NEZPERCE | A US National Historical Park comprising 38 sites located in the states of Idaho, Montana, Oregon and Washington (3,5) |
| RUSHMORE | Mount ---, a mountain in South Dakota and a US national memorial (8) |
| ERIE | Great Lake that isn't Superior, Michigan, Huron, or Ontario |
| ELEE | Part of a US Civil War signature |
| UPTOWN | Residential part of a (US) city (6) |
| SKIDROW | Run-down part of a US city (4,3) |
| ZIPCODE | Final part of a US mailing address (3,4) |
| CORFU | Island in NW Greece |
| LAPALMA | Island in northwest of Canary Islands (2,5) |
| YELLOWSTONE | React to sudden pain next to pit in US National Park (11) |
| TETON | Grand -----, US national park in Wyoming (5) |
| ACADIA | First in an alphabetical list of US national parks |
| BEND | Big ____ is the only US National Park from which you can cross the border into Mexico |
| ZION | US national park with canyon views seen by most tourists from the river rather than the rim |