| INCATRAIL | International barrier with any number of craft regularly passing through: clue for Isthmus of Panama? (4,5) |
| SEWING | Action involved in a number of crafts/ activities including drapery, dressmaking, tailoring and embroidery (6) |
| FREE | Going north from here, craft regularly vacant (4) |
| WHARFINGER | Quay owner, one moaning about American craft regularly (10) |
| OBIT | Lobbyists regularly passing notice |
| TWOBIT | Trashy American town regularly passing notice |
| ELECTRICPIANO | Appoint old police detective with any number of leads for grand type that's wired perhaps (8,5) |
| AZTECAN | Unknown investigator probing teetotal movement with any number of old people |
| HANGERSON | House outside French city with any number of spongers? |
| NOSEGAYS | Goes South with any number of bouquets (8) |
| ATRATO | River rising in Colombia that meanders north across the base of the Isthmus of Panama to the Gulf of Uraba (6) |
| CANALZONE | Former administrative region of the U.S. on the Isthmus of Panama (5,4) |
| SANBLAS | ? Islands, archipelago off the north coast of the Isthmus of Panama |
| AMERICAS | Landmass consisting of two continents connected by the Isthmus of Panama (8) |
| COSTARICA | Republic in Central America on the Isthmus of Panama (5,4) |
| OAXACA | A republic on the Isthmus of Panama (6) |
| VASCO | ___ Nunez de Balboa, Isthmus of Panama explorer |
| MALAY | Also called Kra Peninsula, this long, narrow appendix of Asia extends south for a distance of about 700 miles (1,127 km) through the Isthmus of Kra to Cape Pia. (5) |
| KRA | Isthmus of ___, narrow neck of the Malay Peninsula between the Gulf of Thailand and the Bay of Benga |
| ALTERATION | Change regular pattern of succession with any number dropping out (10) |