| MIRANDA | Innermost of Saturn's five major moons |
| OBERON | Fairy king after whom William Herschel's son named the outermost of Uranus's five major moons (6) |
| RHEA | One of Saturn's major moons |
| MIMAS | The smallest and innermost of the major regular moons of Saturn. It was discovered in 1789 by the English astronomer William Herschel. Its most noteworthy feature is a 130-km- (80-mile-) diameter crat |
| METIS | The innermost of the known moons of Jupiter (5) |
| NAIAD | Innermost of the 16 moons of Neptune, discovered by NASA's Voyager 2 in 1989 (5) |
| AGA | One of the most common of the five major classes of immunoglobulins. |
| OCEAN | Any one of five major bodies of water forming the hydrosphere, collectively covering 70 per cent of Earth's surface (5) |
| ANTARCTICCIRCLE | Most southerly of the five major divisions of latitude that are shown on maps of Earth (9,6) |
| ARCTICCIRCLE | The most northerly of the five major lines of latitude as shown on maps of Earth (6,6) |
| IGG | One of the five major classes of immunoglobulins. |
| IGE | One of the five major classes of immunoglobulins. |
| ANTARCTIC | One of the five major circles of latitude |
| NYC | Site of the HQ of five major sports |
| IAPETUS | The outermost of Saturn's major regular moons, extraordinary because of its great contrast in surface brightness. This moon was discovered by Gian Domenico Cassini in 1671, it has a radius of 718 km ( |
| STAPES | Innermost of the three small bones (auditory ossicles) of the middle ear, transmitting vibrations from the incus to the cochlea (6) |
| IONIC | One of the five major orders of classical Greek architecture (5) |
| UMAMI | One of the five major taste sensations |
| WASHINGTONSTATE | Locale of five major U.S. volcanoes |
| ASHDOD | Israeli port, one of the five major Philistine cities (6) |
