| OTRANTO | Initially old trades were sufficient for an Italian port |
| BLOC | A group of states imposed an embargo on trade, we're told (4) |
| FAIR | Type of trade we're both cool with |
| GENOA | Jib for a sailing vessel in an Italian port |
| GENOESE | Fleming's doctor stuffs birds from an Italian port (7) |
| TRIESTE | Examines a note presented in an Italian port (7) |
| SALERNO | New Orleans is an Italian port (7) |
| BRINDISI | Migrating bird is in an Italian port (8) |
| BARI | Embargo put on one in an Italian port |
| OTIS | Initially, Old Testament is needed for Asa Butterfield's Sex Education role (4) |
| DESERVED | Due diligence's limiting factors were sufficient |
| TOILETRIES | Initially, old European litter is recycled to make soap, shampoo etc. (10) |
| OGHAM | Initially, old German half as mysterious as ancient writing system (5) |
| TOPSOIL | Initially old pilots damaged surface of earth |
| YOGI | Yes, initially old gymnastic Indian, was a practitioner of asceticism (4) |
| OBSESSIONS | Initially, old boys' get-togethers produce manias |
| OBVIOUS | Initially old boys validate promissory notes - it's clear (7) |
| OBTUSE | Initially, old boys tease us, spoiling everything; a bit stupid (6) |
| OPAQUE | Initially old puzzles appear quite unusual, even cryptic (6) |
| ORGAN | Initially, old gran played instrument (5) |
