| SMALLPOX | Infectious disease that was officially declared eradicated from the world in 1980 (8) |
| WASP | Stinging insect, the Asian variety was declared eradicated from Mallorca in 2020 but the aggressive predator, a danger to native insect life, has recently been spotted on the island once more (4) |
| PELE | Athlete who was officially declared a "national treasure" by Brazil in 1961 |
| MALARIA | Disease that was the subject of the second Nobel Prize in Physiology or Medicine (1902) |
| AKITA | Large Japanese dog of the spitz type officially declared a national treasure in 1931 (5) |
| THEWARONDRUGS | Program that a 2011 global commission officially declared a failure, 40 years after its launch |
| BLACKLEG | Infectious disease that can affect cattle, sheep and other livestock (8) |
| RHODESIA | Name by which Zimbabwe was officially known from 1964 to 1979 (8) |
| WATERLOO | This new London bridge built during the Blitz was officially opened on August 11, 1942 |
| ANCHORET | Recluse, one who has withdrawn from the world (8) |
| ASSASSIN | Eve Macarro, by the end of a 2025 "From the World of John Wick" movie |
| SUPERNAL | From the world of the divine |
| CLOISTER | Shut away from the world, seclude (8) |
| CANADIAN | From the world's second largest country (8) |
| HERMETIC | Opponent of Orthodox Church receives Mass, shut off from the world |
| RECLUSES | They are withdrawn from the world |
| CHARON | His duty was to ferry the souls of the newly deceased across the river Styx, which divided the world of the living from the world of the dead. |
| CHOLERA | Infectious disease that saw a worldwide upsurge in 2023 (7) |
| DO | Taekwon___ was officially added to the Games in 2000 in Sydney |
| CHARLES | He was officially crowned king in May in the U.K. (7) |
