| SPACENEEDLE | Iconic observational tower of Seattle which which was the tallest building west of the Mississippi River at the time it was built: 2 wds. |
| DAKOTA | Storied apartment building west of Central Park, with "the" |
| REYNOLDS | Plymptonian knighted master portraitist depicted among fellow academicians of the Royal Academy, along with his silver ear-trumpet, in an iconic observational conversation piece by Johann Zoffany (8) |
| SEAWOLVES | Professional rugby team based in Seattle which plays in the US national league (9) |
| CELEBRITY | One listed building's west wing laid in haste |
| SEARS | Which (___ Tower) in Chicago was the tallest building in the world when completed in 1973? (5) |
| COLOGNE | City on the Rhine; its gothic cathedral was the tallest building in the world, 1880-4 |
| STPAUL | Capital on the Mississippi R. |
| LSU | Southern campus on the Mississippi R. |
| MINN | State where the Mississippi R. originates |
| HOOVERDATUM | "The first occupant of the White House to be born west of the Mississippi River," e.g.? |
| EMPIRESTATE | In 1931 when it was completed, this was the tallest skyscraper in the word; The ... Building (6,5) |
| LEWIS | Meriwether, US explorer who, with Clark, led an expedition to explore the lands to the west of the Mississippi in the early 19c (5) |
| CHEROKEE | The vast majority of this native North American people were forced to move to a reservation west of the Mississippi in 1838 (8) |
| ARKANSAS | US state west of the Mississippi River, nicknamed 'the Natural State' (8) |
| ADAMS | Astronomer who explained the origin of the Leonid meteor swarms, described the motion of the Moon and independently calculated Neptune's position, by mathematical rather than observational means (5) |
| SHARD | The ___ 95-story skyscraper that is the tallest building in the U.K. and the European Union designed by the Italian architect Renzo Piano |
| HERON | ___ Tower, popular name for the tallest building in the City of London financial district (5) |
| ELYSIAN | The ___ tower in Cork is the tallest building in the state. (7) |
| SINGER | ___ Building, company headquarters erected in 1908 in New York City, at the time the tallest building in the world |