| EPOCHAL | Highly significant or important, marking the beginning of a new development or era. (7) |
| VANGUARD | A group of people leading the way in new developments or ideas (8) |
| MATTERS | Is significant or important (7) |
| XES | Important markings on treasure maps |
| HANDSEL | A gift as a token of luck, often at the beginning of a new year (7) |
| SAMHAIN | Celtic festival marking the beginning of winter |
| BISHOPS | Prelates known collectively as an episcopacy; or, chesspieces associated with the development or strategy of fianchettoing (7) |
| SPECIAL | Significant, or strange, places one has lodged in (7) |
| ZYMOSIS | Development or spread of an infectious disease (7) |
| OVATION | New development, dropping one pair of notes, getting great reception (7) |
| ESTATES | Often-rural landed properties; housing developments; or, plantations such as vineyards (7) |
| SCENARIO | An outline or synopsis of the plot of a dramatic or literary work such as a film, novel or play; or, a postulated sequence of possible developments or events (8) |
| ARSENIC | Scare in new development involved with old lace in 1962 TV film (7) |
| VICTORIANA | Bric-a-brac, collectables or objets characteristic of the age or era ruled by a queen whose name is given to a bravery decoration, a cake, a lily and a plum, among many other things (10) |
| INAUGURAL | Of a ceremony officially marking the beginning of something (9) |
| PHASE | A planetary or lunar aspect; a stage in a life cycle, mitosis or one's psychological development; or, a morph or colour change in zoology (5) |
| SEGNO | In musical notation, a symbol marking the beginning or end of a section to be repeated (5) |
| NIMBYISM | The practice of objecting to something, e.g. a new development, in one's own locality (8) |
| PASSINGFANCY | Childhood hurt, experienced at the beginning of a new enterprise (7,5) |
| GROWINGPAINS | Childhood hurt, experienced at the beginning of a new enterprise (7,5) |
