| STEVENUNIVERSE | Half-human half-alien title character in a current Cartoon Network series: 2 wds. |
| CLARENCE | Titular character in a current Cartoon Network series |
| SAMURAIJACK | Sword-wielding title character in a 2001-2004 and 2017 Cartoon Network series: 2 wds. |
| JOHNNYBRAVO | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| MEGAMIND | 2010 animated film in which Will Ferrell voices the blue-skinned alien title character |
| VIETNAMESE | Oriental struggle to retain alien titles (10) |
| AQUATEEN | Any of three title characters in a long-running Cartoon Network series |
| NAGA | A divine half-human, half-cobra being in Hinduism, said to reside in a resplendent jewelled palace (4) |
| POWERPUFFGIRLS | With "The", former Cartoon Network series set to return in 2016...or a hint to the second half of 20 |
| CRAIGOFTHECREEK | Cartoon Network series set in a parent-free forest wonderland |
| TEENTITANS | Heroes in a Cartoon Network series |
| ADVENTURETIME | Award-winning Cartoon Network series with Finn the Human and Jake the Dog |
| EDEDDNEDDY | Cartoon Network series about a trio of similarly named friends |
| TROI | Half-human, half-Betazoid character in Star Trek: The Next Generation, Deanna ... (4) |
| CENTAURUS | In Greek myth, the father of a race of hybrid half-human, half-horse creatures (9) |
| ERMA | Comic series about a girl who is half human, half y?kai |
| OVER | _ The Garden Wall, Cartoon Network series with Elijah Wood and Collin Dean (4) |
| LAMB | 2021 folk horror film featuring a half-human, half-sheep hybrid |
| FAUN | Mythical species of Mr Tumnus, half-human/half-goat, in C.S. Lewis' The Chronicles of Narnia (4) |
| TEEN | Aqua ___ Hunger Force (Cartoon Network series) |
