| RUBE | Goldberg known for his complex chain-reaction machines |
| GOMBERT | Nicolas ___, Franco-Flemish composer of the Renaissance noted for his complex polyphonic compositions |
| BIOCHEMIST | Scientist initially bringing mice to his complex? |
| NIHILISTS | Negative thinkers sit in his complex outside Lima |
| CRITICALMASS | Minimum amount of fissile material for chain reaction |
| CREATE | A chain reaction sandbox video game developed by EA Bright Light for Windows, PlayStation 3, Wii, Xb |
| THEWEAKESTLINK | I eat Kent whelks, prepared for dodgy one that might cause chain reaction? (3,7,4) |
| DOMINO | One of a number of tiles with pips whose arrangement in a toppling sequence illustrates the cumulative effect known as a chain reaction (6) |
| DOMINOS | Pieces in a chain reaction |
| REARENDER | Result of a chain reaction accident, perhaps |
| INRE | With regard to what's discovered in chain reaction (2,2) |
| TRIGGER | Catch agent setting off a chain reaction |
| KNOCKONEFFECT | Consequence, chain reaction (5-2,6) |
| DOMINOEFFECT | A dotty chain reaction? (6,6) |
| FLUSH | Start chain reaction? (5) |
| OUCH | Pinch from a chain reaction |
| DIANAROSS | US female singer of the 1986 chart-topper Chain Reaction (5,4) |
| FERMI | Atomic chain reaction pioneer |
| NUCLEARFUEL | Lance rueful about substance that will sustain fission chain reaction (7,4) |
| INITIATOR | In chemistry, a substance that starts a chain reaction (9) |
