| BIOGEN | Giant in the development of neurological disease therapies |
| NORMANDOTT | Doctor (1897 - 1973), the first Professor of Neurological Surgery at Edinburgh University (6,4) |
| LATHYRISM | Neurological disease causing stiffness and paralysis of the legs in humans and animals (9) |
| EPILEPSY | Which neurological disease is usually characterised by convulsions (8) |
| SUGER | Advisor to both Louis VI and Louis VII whose supervision of the rebuilding of Saint-Denis as its abbot was key in the development of the Gothic architectural style (5) |
| CUTTINGEDGE | Latest or most advanced stage in the development of something, as in trimming the sides of a lawn! (7,4) |
| ABE | ___ Edgington (horse depicted in The Horse in Motion, which is widely regarded as a milestone in the development of motion pictures) |
| ONTOGENESIS | The sequence of events involved in the development of an individual organism |
| YOUTH | Stage of adolescence between childhood and maturity; juveniles collectively; or, the early days in the development of something (5) |
| SPINABIFIDA | Congenital defect in the development of the vertebral column (5,6) |
| CREED | Frederick George ____ was a key figure in the development of the teleprinter |
| RENOIR | Leading painter in the development of the Impressionist style (6) |
| EDISON | Phonograph inventor who was key in the development of the first practical incandescent light bulb (6 |
| LESPAUL | American jazz guitarist and pioneer in the development of the solid-body electric guitar (3,4) |
| PERICLES | Fifth-century BC politician who played a major role in the development of the Athenian empire (8) |
| HESS | Central figure in the development of the Nazi movement under Adolph Hitler, Rudolf ... |
| EDGE | Knife _, a critical point in the development of a situation, process of making a decision, etc (4) |
| INSTAR | The stage in the development of an insect between any two moults (6) |
| GIOTTO | _ Bizzarrini, he played a key role in the development of the Ferrari 250 GTO (6) |
| IRONAGE | Ancient period in the development of mankind (4,3) |
