| MEYERBEER | Giacomo, composer of the 1859 opera Dinorah (9) |
| PUCCINI | Giacomo, composer of the opera Tosca (7) |
| EMMETT | Daniel Decatur, composer of the 1859 song Dixie (6) |
| GONCHAROV | Russian author of the 1859 novel Oblomov (9) |
| DARWINISM | Theory of biological evolution first formulated in the 1859 work On the Origin of Species (9) |
| SOLFERINO | The 1859 battle which inspired the foundation of the Red Cross |
| GOUNOD | Charles, French composer noted for his 1859 opera Faust (6) |
| AMASKEDBALL | English title of an 1859 opera by Giuseppe Verdi (1,6,4) |
| FAUST | 1859 opera by Charles Gounod (5) |
| JOHNSTUARTMILL | English philosopher and economist who wrote the 1859 treatise On Liberty |
| SAMUELSMILES | British writer best known for the 1859 didactic work Self-Help |
| BERTRAMS | The -, 1859 novel by Anthony Trollope |
| CARISSIMI | Giacomo ___, Italian early Baroque composer, noted as one of the first composers of oratorios, such as Jephte |
| BUTTERFLY | Madama ___, 1904 opera by Giacomo Puccini (9) |
| SUSPICION | 1991 film thriller starring Liam Neeson and Laura San Giacomo (5,9) |
| RASPADORI | Giacomo ...., Italy, Napoli and 2019-23 Sassuolo forward (9) |
| ARRHENIUS | Svante August ___, (1859-1927), Swedish chemist and physicist noted for his work on the theory of electrolytic dissociation and his model of the greenhouse effect: Nobel Prize for Chemistry 1903 (9) |
| SUEZCANAL | Artificial waterway in NE Egypt, constructed between 1859 and 1869, linking the Mediterranean at Port Said with the Red Sea (4,5) |
| JOHNBROWN | Leader of infamous 1859 raid |
| THELIFTED | and 19dn, 1859 novella by George Eliot featuring the character Bertha Grant |
