| OTTERPOP | Freezer bar with Sir Isaac Lime and Alexander the Grape flavors |
| NEHI | Soda brand with orange and grape flavors |
| NHL | Org. for Sid the Kid and Alexander the Great |
| GOUT | Ailment for Charlemagne and Alexander the Great |
| ELLIS | Philologist who wrote extensively on the phonology of British dialects and pronunciation and developed a phonotypic alphabet with Sir Isaac Pitman (5) |
| HIC | Brand with a Grabbin' Grape flavor |
| MIRROR | A looking-glass such as the convex specimen represented in Jan van Eyck's Arnolfini Portrait or the concave example in Sir Isaac Newton's reflecting telescope (6) |
| ISAACS | Name the first Australian-born governor-general, Sir Isaac... (6) |
| HEDERA | - helix ; worn as a crown by god of the grape-harvest Dionysus and supporting some 50 species including the blackbird, the Latin name of the native British woodland plant ivy (6) |
| POUNDNOTE | Old money featuring Sir Isaac Newton (5,4) |
| GIFNEWTON | Animated image of an apple falling on Sir Isaac? |
| PITMAN | Sir Isaac ___, inventor of a shorthand system, born 1813 (6) |
| GRAVY | Sir Isaac Newton wrote about this ... Pass it on |
| ROYALMINT | *British moneymaker once overseen by Sir Isaac Newton |
| MUSCAT | Pliny the Elder called it "the Grape of the Bees" |
| ARPEGGIO | With rapid progression, I go the way of the grape imbiber. Strike a chord? |
| NEWTON | English scientist Sir Isaac ... |
| ETHELMERMAN | She was a singer with a powerful voice and a star of stage and screen who sang I Got Rhythm and Alexander's Ragtime Band (5,6) |
| SKARSGARD | Family name of the Swedish father-and-son actors Stellan and Alexander |
| WINED | Supplied with the grape, so to speak |
