| CANALZONE | Former administrative region of the U.S. on the Isthmus of Panama (5,4) |
| COSTARICA | Republic in Central America on the Isthmus of Panama (5,4) |
| OAXACA | A republic on the Isthmus of Panama (6) |
| ATRATO | River rising in Colombia that meanders north across the base of the Isthmus of Panama to the Gulf of Uraba (6) |
| INCATRAIL | International barrier with any number of craft regularly passing through: clue for Isthmus of Panama? (4,5) |
| SANBLAS | ? Islands, archipelago off the north coast of the Isthmus of Panama |
| DEEPSOUTH | Region of the U.S. (4,5) |
| AMERICAS | Landmass consisting of two continents connected by the Isthmus of Panama (8) |
| LIMOUSIN | A former administrative region of West-Central France, the capital of which was Limoges (8) |
| AUVERGNE | Former administrative region of France comprising the departments of Allier, Puy de Dome, Cantal and Haute Loire |
| CORINTH | The Isthmus of - connects the Peloponnesus with the mainland of Greece (7) |
| KRA | The Isthmus of --- is the narrowest part of the Malay Peninsula (3) |
| PARTSOFKESTEVEN | Former administrative region of Lincolnshire from which the baronetcy created for Margaret Thatcher in 1992 is named (5,2,8) |
| PELOPONNESE | The - - -, southern peninsula of Greece, joined to central Greece by the Isthmus of Corinth (11) |
| MALAY | Also called Kra Peninsula, this long, narrow appendix of Asia extends south for a distance of about 700 miles (1,127 km) through the Isthmus of Kra to Cape Pia. (5) |
| TAYSIDE | Former administrative region of central eastern Scotland (7) |
| MACAU | Former Portuguese colony that is now a Special Administrative Region of the People's Republic of Chi |
| RUSHMORE | Mount --, national memorial in the U.S. on which are carved the faces of four American presidents (8) |
| NOVASCOTIA | It's connected to New Brunswick by the Isthmus of Chignecto |
| PEARLHARBOR | Where the Japanese attacked the U.S. on December 7, 1941: 2 wds. |