| BADAPPLE | First in barrel has a spotted marking: it infects the rest |
| THRUSH | Which garden songbird has a spotted breast? (6) |
| VIRUS | What infects the old man from Rome? Us! (5) |
| MICROBE | It infects more than one mouse about to steal (7) |
| RUNDRY | What the sprinters do when the barrel has! (3,3) |
| ECOLI | City oil scandal is something liable to infect the entire system (1,4) |
| SAWNOFF | Truncated, as a modified shotgun barrel has been |
| MOTTLING | MG, not lit if marking it with splotches (8) |
| MILDEW | It infects in not too serious ways (6) |
| BLUECAP | A titmouse; a flame-like folkloric mine fairy; a one-year-old salmon with a spotted head; or, a Balmoral bonnet, hence a Shakespearean or colloquial term for a Scotsman (7) |
| SNOOPY | He is a spotted white beagle who is Charlie Brown's pet dog and appears in Peanuts cartoons. In this dog's fantasy life, he plays a World War I flying ace whose nemesis is the Red Baron. |
| DIE | A dado, plinth or other cubical part of a pedestal; a stamp for impressing coins or medals; or, from "dare to give/play", a spotted cube thrown in games of chance (3) |
| LEAFINSECT | Camouflaged bug infects ploughed meadow first (4,6) |
| LITTERBUG | What infects young puppies like a wilfully untidy person? (6-3) |
| GERMAN | Hamburger, say, one that infects a number (6) |
| LADYBUG | US term for a spotted beetle in the family Coccinellidae (7) |
| BRINDLE | Led in the wrong way behind British railways, like a spotted dog (7) |
| HYENA | A spotted one might be spotted at the zoo |
| TWISTER | A tornado; or, a game of contortionism on a spotted mat (7) |
| AGARIC | Fungus infects a cigar |
