| TIBIANIGHTFEVER | Film with the second-best-selling soundtrack of all-time [shin] |
| SCREAM | Riot with the second best part of society (6) |
| ARISTA | Record label that released the best-selling soundtrack to "The Bodyguard" |
| MINECRAFT | After Tetris, the second-best-selling video game of all time |
| GTAV | The second-best-selling video game of all time, briefly |
| WIFE | Big-selling soundtrack "The Preacher's ___" |
| LICENSEDTOKILL | 1965 film starring Tom Adams as secret agent Charles Vine, released in the US under the title The Second Best Secret Agent in the Whole Wide World |
| ADAGE | "The best time to plant a tree was 20 years ago. The second-best time is now," e.g. |
| WINTER | - Wonderland; Christmas song forming part of the soundtrack of the 2006 film The Holiday (6) |
| ALPHA | The first Greek letter that, with the second letter "beta", forms the origin of the name given to a system of letters we use to write (5) |
| FINNEGANSWAKE | Which James Joyce novel opens with the second half of the sentence that starts at the very end of the book? (9,4) |
| ADLER | Larry ____ played the harmonica on the soundtrack of the film Genevieve |
| ENYA | Ireland's second-best-selling musical artist (behind U2) |
| ANNEHATHAWAY | The wife of William Shakespeare, to whom he left the 'second-best bed' in his will |
| FRANKOCEAN | His "Blonde" was named the second-best album of 2016 by Pitchfork: 2 wds. |
| PEKOE | Poke out the second best kind of tea |
| IMRIE | A star of The Second Best Exotic Marigold Hotel (5,5) |
| CELIA | A star of The Second Best Exotic Marigold Hotel (5,5) |
| EXOTIC | 2015 comedy film, The Second Best - - - Marigold Hotel (6) |
| ROWB | Where to find the second best seats in the house |
