| KINGSCROSS | Family angry about limitations to genetics? It's a point of departure (5,5) |
| CASTERSUGAR | Performers argue vaguely about limitations to roles? It's sweet |
| MENDELISM | Theory that led to genetics |
| DRESSMAKER | Seamstress carelessly remarked about limitations of skirts? (10) |
| HELLODOLLYDOLLY | Broadway revival dealing with genetics? |
| HERITARY | Determined by genetics? |
| ADAMANDEVE | Turns up, first lady is linked to genetic material on bananas and primarily on apples produced by the gardeners (4,3,3) |
| ANGLE | Had no time to get involved. It's a point of view (5) |
| HOTEL | Mostly very good about limitations of the accommodation |
| DOTAGE | Function, thanks to genetic engineering, in second childhood (6) |
| MUTANT | Subject to genetic change |
| OHMSLAW | 20 down is eaten as a small salad - it's a point of principle for a conductor (3'1,3) |
| DIGRESSION | What may seem like a point of departure is a departure from the point. (10) |
| GATWICK | Where Patrick and I got war novel, "A Point of Departure" (7,7) |
| SPRINGBOARD | Time the directors had a point of departure (11) |
| IDEA | 'A point of departure and no more': Picasso |
| AERODROME | Adore to travel to city from point of departure (9) |
| PERUSAL | Paddington's point of departure, and leads to Slough, Acton, Langley and Reading (7) |
| SEEOFF | Accompany to point of departure or chase away (3,3) |
| INDEPENDENCE | City in Missouri, US; point of departure of the California, Oregon and Santa Fe Trails in the 19th c |
