| SORORAL | Extremely red of mouth, like a sister (7) |
| HODAKOTB | "Today" star who says her coanchor Savannah Guthrie is like a sister to her: 2 wds. |
| SISTERLY | Like a sister |
| CLARETS | Irish county tries extremely red wines (7) |
| PONCEAU | French word for the scarlet red of the corn poppy, hence a dye of vivid rouge colour, like said coquelicot (7) |
| OSCULUM | Mouth-like aperture in a sponge through which water is expelled; from Latin, 'little mouth' (7) |
| OSCULAR | Pertains to a sponge's mouth-like opening |
| ORIFICE | Mouth-like opening (7) |
| OSCULES | Mouth-like openings in sponges |
| MANOWAR | Big Red of horse racing |
| SKELTON | Comic "Red" of vaudeville, radio, TV, and film |
| ORAL | Taken by mouth, like a medication |
| RABID | Foaming at the mouth, like a dog |
| CERISE | A colour of achilleas, blood, Crayola crayons, cricket balls, fashion statements, rubies or tiny tomatoes the size of berries, all like the vivid fuchsia-, magenta- or rose-like pinkish-red of shiny F |
| OPAL | Siliceous gem with kaleidoscopic colours said by Pliny to encompass the blue of sapphire, the green of emerald, the purple of amethyst, the red of ruby and the yellow of topaz (4) |
| CHROMIUM | The chameleon of the periodic table, named for the remarkable changing "colour" of its compounds, found in the green of emeralds, red of rubies and the yellow of oil paint in which it abounds (8) |
| BLOWINGOFF | Removing with a puff of air from one's mouth, like dust from something old: 2 wds. (Theme answer: The circled letters spell a synonym for "pal.") |
| ERO | Extremely Red Object (astronomy) (abbr) (3) |
| CARDINAL | Main channel filled with extremely red iodine (8) |
| DELTA | River mouth, like that of the Nile (5) |