| REDHEADED | Eponymous League investigated in the second of Sir Arthur Conan Doyle's Sherlock Holmes short stories (3-6) |
| NEILMAGANTNER | Which US-born Australian writer used the pseudonym of Neilma Sidney and wrote Sunday Evening: storie |
| STRAND | Magazine in which the Sherlock Holmes short stories were first published (6) |
| UFO | Sky vehicle investigated in "The X-Files": Abbr. |
| MYCROFT | Older brother of Sir Arthur Conan Doyle's Sherlock Holmes (7) |
| SIGN | The _ of the Four: written in 1890, the second of Arthur Conan Doyle's Sherlock Holmes novels (4) |
| ASTUDYINSCARLET | Debut novel of Arthur Conan Doyle's Sherlock Holmes and Dr. Watson, published in 1887 (1,5,2,7) |
| LASSUS | Celebrated in a matinee at the 2015 Proms, composer whose "polyphonic motets" are a favourite of Sir Arthur Conan Doyle's character Sherlock Holmes (6) |
| POISONDART | Cause of death in Sir Arthur Conan Doyle's "The Sign of the Four" |
| HOLMES | Detective in Sir Arthur Conan Doyle's novels including A Study in Scarlet and The Hound of the Baskervilles (6) |
| MORIARTY | Professor _, archenemy of Conan Doyle's Sherlock Holmes (8) |
| ADLER | Irene --, character in the Sherlock Holmes stories of Sir Arthur Conan Doyle (5) |
| STUDY | A - in Scarlet; Sir Arthur Conan Doyle's first novel to feature Sherlock Holmes and Dr Watson (5) |
| DOCTORWATSON | Sherlock Holmes's friend and assistant in Sir Arthur Conan Doyle's stories (6,6) |
| WATSON | Dr John ---, Sherlock Holmes' friend and assistant in Sir Arthur Conan Doyle's stories (6) |
| HORNUNG | Sir Arthur Conan Doyle's brother-in-law who created Sherlock Holmes's supposed "criminal twin" Raffles (7) |
| CHIASMI | Reversal of the order of words in the second of two parallel phrases. (7) |
| BOMBER | Nickname of Sir Arthur Harris, marshal of the Royal Air Force during the Second World War (6) |
| ELEMENTARY | TV series with Jonny Lee Miller and Lucy Liu which is a modern-day take on Sir Arthur Conan Doyle's character Sherlock Holmes |
| BELL | Surgeon who partly inspired Arthur Conan Doyle's character Sherlock Holmes; or, any one of a series of musical instruments forming the chime of a carillon (4) |
