| JAMESTOWN | England's first permanent settlement in North America |
| MARIETTA | Ohio town that was the first permanent settlement in the state (1788) |
| OGDEN | First permanent settlement by people of European descent in what is now Utah |
| VIRGINIA | US state that saw North America's first permanent English settlement (8) |
| FATHERS | Founders of the first permanent colony in New England in 1620 (7,7) |
| PILGRIM | Founders of the first permanent colony in New England in 1620 (7,7) |
| ALDERSHOT | Hampshire town in which the first permanent training camp for the British Army was established in 1854 (9) |
| BALBOA | Explorer who founded the first permanent European settlement on the mainland of the Americas (in present day Panama) |
| RUSSELL | New Zealand's first permanent European settlement (7) |
| PERU | South American home of the world's highest permanent settlement, La Rinconada |
| ASTORIA | Oregon city that was the first permanent U.S. settlement west of the Rockies |
| MIR | The first permanent orbiting space station, destroyed by a controlled descent into the Earth's atmosphere in 2001 (3) |
| NARA | City in central Japan which was the first permanent capital of the country (4) |
| EBAN | Israel's first permanent UN delegate |
| KERIKERI | Site of NZ's first permanent mission station (8) |
| WALLSTREET | First permanent home of the New York Stock Exchange (4,6) |
| WAR | Clinton has approved a treaty to create the world's first permanent ___ crimes court |
| OVAL | The -; cricket ground that hosted England's first ever Test Match in 1880, where the Ashes were created in 1882 (4) |
| QUANTOCKHILLS | Area in the South West which was England's first Area of Outstanding Natural Beauty, designated in 1956 (8,5) |
| BEHN | England's first known professional female writer, interred in Westminster Abbey in 1689 (4) |
