| MMII | Early in the 21st century |
| WOOTTON | Small town in Wiltshire, recognised for its role in military funeral repatriations in the 21st Century (5,7,7) |
| ROYAL | Small town in Wiltshire, recognised for its role in military funeral repatriations in the 21st Century (5,7,7) |
| BASSETT | Small town in Wiltshire, recognised for its role in military funeral repatriations in the 21st Century (5,7,7) |
| CHICAGO | The only musical to have won the Oscar for Best Picture in the 21st century (7) |
| LETITGO | First Disney song to reach the top 5 on Billboard in the 21st century |
| OBAMA | Only US president to win the popular vote twice in the 21st century |
| NOWADAYS | In the 21st century (8) |
| COOL | "Groovy!" in the 21st century |
| SASHA | White House resident born in the 21st century |
| ALPHA | Generation ___, first to be born in the 21st century |
| POPES | Benedict and Francis, in the 21st century |
| DATA | Something mined in the 21st century |
| JOHNROBERTS | First Supreme Court justice confirmed in the 21st century (2005): 2 wds. |
| SONIASOTOMAYOR | Third Supreme Court justice confirmed in the 21st century (2009): 2 wds. |
| SAMUELALITO | Second Supreme Court justice confirmed in the 21st century (2006): 2 wds. |
| BROKEBACKMOUNTAIN | Couple in the 21st century with Best Director Oscar winners |
| SPAIN | Home to more World Championship races than any other country in the 21st century. (5) |
| ISLANDS | ___ in the Sky 1952 sci-fi novel by Arthur C. Clarke that is set in the later half of the 21st century |
| MILLENNIUMBUG | Computer problem arising from the change in date at the start of the 21st century |
