| LACLEDE | Early French pioneer in the United States |
| PINEL | French pioneer in treating the mentally ill |
| PASTEUR | Louis ___, 19th-century French pioneer in microbiology (7) |
| LAPLACE | French pioneer in planetary orbital theory |
| ACADIAN | Any of the early French settlers in Nova Scotia, many of whom were deported to Louisiana in the 18th century |
| VERNE | French pioneer of science fiction and author of Journey To The Centre Of The Earth, Jules ... |
| DAGUERRE | Louis ___, French pioneer of early photography (8) |
| CREOLE | Person descended from the early French settlers in Louisiana (6) |
| LESPAUL | American jazz guitarist and pioneer in the development of the solid-body electric guitar (3,4) |
| LUCILLEBALL | Sitcom pioneer in the first class of inductees to the Television Academy Hall of Fame |
| VERDI | Venerated Italian composer, a pioneer in the eld of opera, made a senator in 1874 (5) |
| EULER | Pioneer in the math of sudoku |
| MACH | Pioneer in the study of supersonic velocities |
| HARRAH | Pioneer in the Nevada gaming industry |
| ENRICO | Italian physicist and pioneer in the nuclear reactor industry, ... Fermi |
| ENID | Female pioneer in the male-dominated world of sculpting, ... Yandell |
| STOPES | Marie _, English pioneer in the field of family planning (6) |
| RHODES | Colonial pioneer in the Dodecanese (6) |
| ATARI | Video game pioneer in the 1970s |
| NADER | Ralph --, American pioneer in the field of consumer protectionism (5) |
