| NEGATIVEEQUITY | Domestic problem of depression in film actors' guild (8,6) |
| BODYDOUBLE | Stand-in film actor for stunt or nude scenes (4,6) |
| UNEMPLOYMENT | The problem of depression? (12) |
| CHARLTONHESTON | "Planet of the Apes" actor who was president of the Screen Actors Guild, 1965-1971: 2 wds. |
| HOUSEMAIDSKNEE | Domestic problem upsetting for hodman, I seek outside employment (10,4) |
| BOREDOM | Ennui, to do with onset of depression in period of success? |
| AYOEDEBIRI | She won Outstanding Performance by a Female Actor in a Comedy Series for her portrayal of Sydney Adamu in "The Bear" at the Screen Actors Guild Awards last night |
| CLOWNS | Performs grotesquely because of depression in central nervous system (6) |
| GLOOM | Feeling of depression in semi-darkness (5) |
| MANIA | Counterpart of depression, in bipolar disorder |
| RISINGDAMP | Rebellion with pressure to involve mother in domestic problem |
| THECOOK | Start of a quip about a domestic problem by H.H. Munro |
| ROBERTDENIRO | Killer of the flower Moon actor who received the Screen Actors Guild's Life Achievement Award in 2019: 3 wds. |
| ASNER | US actor and former president of the Screen Actors Guild, Ed ___ (5) |
| EDASNER | 2001 recipient of the Screen Actors Guild Life Achievement Award |
| KEYE | Luke of "Kung Fu" who co-founded the Screen Actors Guild |
| BELALUGOSI | Horror-movie actor who was a founding member of the Screen Actors Guild |
| DRYROT | Tedious nonsense, domestic problem (3,3) |
| JAMIELEE | Curtis who won the Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Supporting Role on Sunday |
| TALBOT | Screen Actors Guild co-founder Lyle __ |
