| GUARDED | Discreet informal name for a drug product (7) |
| ACTIFED | Trade name for a drug containing an antihistamine and a decongestant. |
| ANALGESIA | Generic name for a drug that acts to relieve pain (9) |
| LIBRIUM | A£1 given to one in Birmingham for a drug (7) |
| ASPIRIN | Aspiring gang leader went for a drug (7) |
| READIES | Tour helpers trading love for a drug and cash (7) |
| USELESS | Futile advice for a drug addict? |
| MINARET | Informal name for a 2-8-2T locomotive created for logging railroads in America (7) |
| CHOPPER | An informal name for a helicopter (7) |
| MOUNTIE | Informal name for a member of the Royal Canadian Mounted Police (7) |
| TIDDLER | Informal name for a very small fish or aquatic creature (7) |
| DROPTOP | Informal name for a convertible (4-3) |
| COPSHOP | Informal name for a police station (3,4) |
| FLEAPIT | Informal name for a run-down cinema |
| HYPE | Abbreviation of a name for a hollow needle, thus a slang word for a drug addict; or, advertising, ballyhoo, excitement, puffery and razzmatazz (4) |
| PUG | An old word for a fox; an informal name for a boxer; an animal's footprint; or, a little carlin with a curled tail and a wrinkled face, whose snorts and snuffles inspired its collective name "grumble" |
| XTC | British band whose name is also slang for a drug |
| CZAR | Informal title for a drug policy honcho |
| NARCOTIC | Name an alternative term for a drug (8) |
| VIAL | A little glass ampoule for a drug, liquid, potion, vaccine etc (4) |
