| YONNE | Department in the Bourgogne-Franche-Comte region of France named after a river that runs through it |
| BESANCON | Capital of Franche-Comte region in north-east France (8) |
| ISERE | French department or a river that runs through it |
| SANTAANA | City in Orange County, or the often congested freeway that runs through it |
| SAINTOMER | Commune in the Pas-de-Calais department of France named after a man who brought Christianity to the area |
| ELYSEE | - Palace; residence of the president of France, named after a neighbouring promenade (6) |
| INDRE | A department of Central France, named after a river (5) |
| ESSONNE | Department in the Ile-de-France region named after a river which is a tributary of the Seine (7) |
| GERS | A department of South West France, named after a tributary of the Garonne (4) |
| MARENGO | The warhorse of Napoleon I of France. named after an 1800 battle (7) |
| EBOLA | Deadly fever, named after a river in the Democratic Republic of the Congo, resulting from a viral in |
| TYNESIDE | In which northern English district, named after a river, is Jarrow in the south and Whitley Bay in the north? (8) |
| RUHR | Industrialised area in western Germany named after a river flowing through the region (4) |
| NILEBLUE | Named after a river, a peacock- or teal-like hue, but less green; one of the colours of Smythson stationery (4,4) |
| ROUSE | Wake in river, a river that runs through York |
| OUTLET | A river that runs out of a body of water (6) |
| RHENIUM | Element named after a river on the France-Germany border |
| AIREDALETERRIER | Dog with black and tan coat, named after a river in Yorkshire (8,7) |
| THEBLUENILE | Scottish band named after a river in Sudan and Ethiopia (3,4,4) |
| APOGEE | Expression of surprise after a river in Italy shows longest point in orbit |
