| EMMETT | Daniel Decatur, composer of the 1859 song Dixie (6) |
| MEYERBEER | Giacomo, composer of the 1859 opera Dinorah (9) |
| GONCHAROV | Russian author of the 1859 novel Oblomov (9) |
| DIXIE | Informal name for the Southern states of the US, from the title of a song written by Daniel Decatur Emmett in 1859 (5) |
| SOLFERINO | The 1859 battle which inspired the foundation of the Red Cross |
| DARWINISM | Theory of biological evolution first formulated in the 1859 work On the Origin of Species (9) |
| JOHNSTUARTMILL | English philosopher and economist who wrote the 1859 treatise On Liberty |
| SAMUELSMILES | British writer best known for the 1859 didactic work Self-Help |
| BERTRAMS | The -, 1859 novel by Anthony Trollope |
| EVERS | Medgar of Decatur |
| STIPE | Michael born in Decatur, Georgia |
| IMP | Small supernatural creature, as in 'Derby ___' and Fuchsia 'Decatur ___'! (3) |
| WAFFLEHOUSE | Breakfast chain with a museum in Decatur, Georgia |
| SSE | Peoria-to- Decatur dir. |
| HOWE | Nation builder Clarence Decatur |
| GOUNOD | Composer of the opera Faust (1859) (6) |
| DARWIN | Charles ?, author of 1859 scientific work On the Origin of Species by Means of Natural Selection (6) |
| SEURAT | Georges ___ (1859-91), French painter who founded the Neo-Impressionist movement and pioneered the technique of pointillism (6) |
| BRUNEL | English engineer, 1806-1859, leading figure in the Industrial Revolution, who built the Great Western Railway and a series of transatlantic steamships (8,7,6) |
| ORIGIN | On the - of Species, Darwin's 1859 publication on evolution (6) |